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Chemical Structure : ES 936
Catalog No.: PC-60680Not For Human Use, Lab Use Only.
A potent, specific mechanism-based human NAD(P)H: quinone oxidoreductase 1 (NQO1) inhibitor that demonstrates efficient inactivation of NQO1 at 100 nM in in cellular systems.
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A potent, specific mechanism-based human NAD(P)H: quinone oxidoreductase 1 (NQO1) inhibitor that demonstrates efficient inactivation of NQO1 at 100 nM in in cellular systems; does not inhibit other cellular reductases, nor does it alter cellular levels of acid-soluble thiols; abrogates the toxicity of streptonigrin, with greater effects seen in cell lines expressing higher levels of NQO1.
| M.Wt | 356.334 | |
| Formula | C18H16N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dehn DL, et al. Mol Pharmacol. 2003 Sep;64(3):714-20.
2. Winski SL, et al. Biochemistry. 2001 Dec 18;40(50):15135-42.
3. Anwar A, et al. J Biol Chem. 2003 Mar 21;278(12):10368-73.
4. Gustafson DL, et al. J Pharmacol Exp Ther. 2003 Jun;305(3):1079-86.
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