Catalog No.: PC-25062Not For Human Use, Lab Use Only.
ESK-001 (Envudeucitinib) is a novel allosteric, highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) with IC50 of 104-149 nM in human whole blood, binds to JH2 domain of TYK2.
ESK-001 (Envudeucitinib) is a novel allosteric, highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) with IC50 of 104-149 nM in human whole blood, binds to JH2 domain of TYK2.
ESK-001 (Envudeucitinib) has no off‐target effects on other kinases (IC50 of >30,000 nM for JAK1‐3).
ESK-001 (Envudeucitinib) significantly inhibited STAT phosphorylation and downstream IFNγ production stimulated by IL‐12, IL‐23, and IFNα in human whole blood and peripheral blood mononuclear cells in a concentration‐dependent manner.
