Catalog No.: PC-25063Not For Human Use, Lab Use Only.
Envudeucitinib hydrochloride (ESK-001 hydrochloride) is a novel allosteric, highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) with IC50 of 104-149 nM in human whole blood, binds to JH2 domain of TYK2.
Envudeucitinib hydrochloride (ESK-001 hydrochloride) is a novel allosteric, highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) with IC50 of 104-149 nM in human whole blood, binds to JH2 domain of TYK2.
ESK-001 (Envudeucitinib) has no off-target effects on other kinases (IC50 of >30,000 nM for JAK1-3).
ESK-001 (Envudeucitinib) significantly inhibited STAT phosphorylation and downstream IFNγ production stimulated by IL-12, IL-23, and IFNα in human whole blood and peripheral blood mononuclear cells in a concentration-dependent manner.
