Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : EVT-701
Catalog No.: PC-38785Not For Human Use, Lab Use Only.
EVT-701 is a highly potent, selective, and safe mitochondrial complex 1 (MC1) inhibitor, reduces NADH abundance with IC50 of 300 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
EVT-701 is a highly potent, selective, and safe mitochondrial complex 1 (MC1) inhibitor, reduces NADH abundance with IC50 of 300 nM.
EVT‐701 dose‐dependently inhibits NADH oxidation and phosphorylation of ADP into ATP by 80% at 7.5 uM.
EVT‐701 inhibits mitochondrial ATP production at nanomolar concentrations in 3 cell lines (IC50 values of 52, 81 and 74 nM for MD‐MB‐231, Hep3B, and U87, respectively).
EVT‐701 dose‐dependently inhibits mitochondrial ATP production with IC50 of 393 nM and proliferation with IC50 of 188 nM in OxPhos‐dependent NH B‐cell lymphomas.
EVT‐701 inhibits OxPhos metabolism and proliferation of non‐small cell lung cancer (NSCLC) lines in vitro and in vivo.
EVT‐701 potently inhibits mitochondrial ATP production (IC50 of 203 nM) and proliferation of H460 cells (IC50 of 68 nM), but also induces apoptosis with an IC50 of 96 nM.
| M.Wt | 629.724 | |
| Formula | C35H35NO8S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Raquel Luna Yolba, et al. Pharmacol Res Perspect. 2021 Oct;9(5):e00854.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
