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Chemical Structure : EXEL-0346
Catalog No.: PC-61427Not For Human Use, Lab Use Only.
EXEL-0346 (EXEL0346) is a novel potent, orally active Glucosylceramide synthase (GCS) inhibitor with IC50 of 2 nM.
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EXEL-0346 (EXEL0346) is a novel potent, orally active Glucosylceramide synthase (GCS) inhibitor with IC50 of 2 nM.
EXEL-0346 decreases glucosylceramide synthesis and ganglioside GM1 synthesis in A549 cells with IC50 of 15 nM.
EXEL-0346 robustly improves glucose tolerance in diet induced obese mice and ZDF rats, decreases plasma triglycerides and reduces hepatic fat deposition.
EXEL-0346 exhibits excellent oral bioavailability coupled with the long half-life.
| M.Wt | 580.446 | |
| Formula | C27H29BrF3N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Richards S, et al. J Med Chem. 2012 May 10;55(9):4322-35.
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