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Chemical Structure : EXEL-8232
Catalog No.: PC-61277Not For Human Use, Lab Use Only.
A potent and selective, orally bioavailable JAK2 inhibitor with IC50 of 2 nM.
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A potent and selective, orally bioavailable JAK2 inhibitor with IC50 of 2 nM; displays >10-fold selectivity over JAK1, JAK3 and Tyk2, and 56 other tyrosine and serinethreonine kinases; inhibits proliferation of SET-2 and UKE-1 cells with IC50 of 177 and 146 nM respectively; effectively treats thrombocytosis and extramedullary hematopoiesis in a murine model of myeloproliferative neoplasm induced by MPLW515L.
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| Appearance | Solid | |
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10 mM in DMSO |
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