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Chemical Structure : Elacridar
CAS No.: 143664-11-3
Catalog No.: PC-45887Not For Human Use, Lab Use Only.
Elacridar (GF120918, GW-0918) is a potent inhibitor of multidrug resistance (MDR, P-gp) that fully reverses multidrug resistance CHRC5, OV1/DXR and MCF7/ADR cells to the cytotoxicity of doxorubicin and vincristine with IC50 of 0.02 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $168 | In stock | |
| 100 mg | $248 | In stock | |
| 200 mg | $400 | In stock | |
| 500 mg | Get quote | ||
| 1 g | Get quote |
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Elacridar (GF120918, GW-0918) is a potent inhibitor of multidrug resistance (MDR, P-gp) that fully reverses multidrug resistance CHRC5, OV1/DXR and MCF7/ADR cells to the cytotoxicity of doxorubicin and vincristine with IC50 of 0.02 uM.
Elacridar (GF120918, GW-0918) effectively competes with [3H]azidopine for binding P-glycoprotein.
Elacridar (GF120918, GW-0918) restores sensitivity of the tumor to a single dose of doxorubicin in mice; orally bioavailable.
| M.Wt | 563.6429 | |
| Formula | C34H33N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-Acridinecarboxamide, N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo- |
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1. Hyafil F, et al. Cancer Res. 1993 Oct 1;53(19):4595-602.
2. den Ouden D, et al. Leukemia. 1996 Dec;10(12):1930-6.
3. Witherspoon SM, et al. Clin Cancer Res. 1996 Jan;2(1):7-12.
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