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Chemical Structure : Elbasvir
CAS No.: 1370468-36-2
Catalog No.: PC-21353Not For Human Use, Lab Use Only.
Elbasvir (MK-8742) is a potent, tetracyclic indole-based HCV NS5A inhibitor, shows broad HCV genotype activity with IC50 of 0.003, 0.003, 0.004, 0.5, 2.4 nM for genotype 1b, 2a, 1a, 1aL31V and 1aY93H, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $398 | In stock | |
| 1 g | Get quote |
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Elbasvir (MK-8742) is a potent, tetracyclic indole-based HCV NS5A inhibitor, shows broad HCV genotype activity with IC50 of 0.003, 0.003, 0.004, 0.5, 2.4 nM for genotype 1b, 2a, 1a, 1aL31V and 1aY93H, respectively.
Elbasvir (MK-8742) shows an increased potency against clinically relevant resistance variants.
Elbasvir (MK-8742) exhibits antiviral activity against several HCV genotypes (including 1a, 1b, 2a, 3a, 4a) with decreased potency against genotype 2b.
| M.Wt | 882.02 | |
| Formula | C49H55N9O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
dimethyl ((2S,2'S)-((2S,2'S)-(((S)-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-1,2-diyl))dicarbamate |
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1. Coburn CA, et al. ChemMedChem. 2013 Dec;8(12):1930-40.
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