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Chemical Structure : Emprumapimod
Catalog No.: PC-73415Not For Human Use, Lab Use Only.
Emprumapimod (PF-07265803) is a potent, selective and orally bioavailable inhibitor of p38 MAPK, inhibits LPS-induced IL-6 production in RPMI-8226 cells with IC50 of 0.1 nM.
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Emprumapimod (PF-07265803) is a potent, selective and orally bioavailable inhibitor of p38 MAPK, inhibits LPS-induced IL-6 production in RPMI-8226 cells with IC50 of 0.1 nM.
Emprumapimod (PF-07265803) (30 mg/kg, p.o.) inhibited LPS induced IL-6 and TNF-alpha by 91% and 95% in SCID-beige mice.
Emprumapimod (PF-07265803) (30 mg/kg, BID, PO) inhibited RPMI 8226 tumor growth by 72% as a single agent in MM xenograft models.
Emprumapimod (PF-07265803) inhibited LPS-induced phosphorylation of p38 in RPMI-8226 xenografts.
| M.Wt | 473.525 | |
| Formula | C24H29F2N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dale Wright, et al. Blood (2006) 108 (11): 3478.
2. Antoine Muchir, et al. Hum Mol Genet. 2012 Oct 1;21(19):4325-33.
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