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Endosidin 9

Chemical Structure : Endosidin 9

CAS No.: 693806-53-0

Endosidin 9 (Clathrin inhibitor ES9)

Catalog No.: PC-72982Not For Human Use, Lab Use Only.

Endosidin 9 (ES9) is a novel mitochondrial uncoupler, and a potent inhibitor of clathrin-mediated endocytosis (CME) in different systems, strongly reduces FM4-64 uptake in Arabidopsis root cells with IC50 of 5 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Endosidin 9 (ES9) is a novel mitochondrial uncoupler, and a potent inhibitor of clathrin-mediated endocytosis (CME) in different systems, strongly reduces FM4-64 uptake in Arabidopsis root cells with IC50 of 5 uM.
Endosidin 9 (ES9) inhibits CME dynamics and organelle movement in the cytoplasm.
Endosidin9 (ES9) inhibits clathrin-mediated endocytosis largely through cytoplasmic acidification.

Physicochemical Properties

M.Wt 363.2
Formula C10H7BrN2O4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Month
Shipping
Solubility

Chemical Name/SMILES

References

1. Dejonghe W, et al. Nat Chem Biol. 2019 Jun;15(6):641-649.

2. Dejonghe W, et al. Nat Commun. 2016 Jun 8;7:11710.

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