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Epaldeudomide

Chemical Structure : Epaldeudomide

CAS No.: 1918159-31-5

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Epaldeudomide (KPG-818, KPG818)

Catalog No.: PC-24133Not For Human Use, Lab Use Only.

Epaldeudomide (KPG-818) is a molecular glue modulator of the E3 ubiquitin ligase complex CRL4-CRBN, shows high cereblon (CRBN) binding affinity and potent degradation of Aiolos (IKZF3) and Ikaros (IKZF1), possesses remarkable broad-spectrum immunomodulatory effects, anti-angiogenic, and anti-tumor effects.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Epaldeudomide (KPG-818) is a molecular glue modulator of the E3 ubiquitin ligase complex CRL4-CRBN, shows high cereblon (CRBN) binding affinity and potent degradation of Aiolos (IKZF3) and Ikaros (IKZF1), possesses remarkable broad-spectrum immunomodulatory effects, anti-angiogenic, and anti-tumor effects.

    Physicochemical Properties

    M.Wt 468.50
    Formula C25H25DFN3O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2,6-Piperidinedione-3-d, 3-[4-[[2-fluoro-4-(4-morpholinylmethyl)phenyl]methoxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, (3S)-

    References

    1. Patent WO2016065980 A1.

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