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Chemical Structure : Etomoxir
CAS No.: 124083-20-1
Catalog No.: PC-45827Not For Human Use, Lab Use Only.
Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) that inhibits fatty acid β-oxidation in rat liver with IC50 of 5-20 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) that inhibits fatty acid β-oxidation in rat liver with IC50 of 5-20 nM.
Etomoxir affects ketogenesis, cholesterol synthesis, and gluconeogenesis both in vitro and in vivo.
Etomoxir decreases viability in LNCaP, VCaP, and patient-derived benign and prostate cancer cells, associated with decreased AR expression, decreased mTOR signaling, and increased caspase-3 activation.
Etomoxir decreases xenograft growth in mice.
| M.Wt | 326.8151 | |
| Formula | C17H23ClO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester, (2R)- |
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1. Lopaschuk GD, et al. Circ Res. 1988 Dec;63(6):1036-43.
2. Kruszynska YT, et al. Biochem Pharmacol. 1987 Nov 15;36(22):3917-21.
3. Schlaepfer IR, et al. Mol Cancer Ther. 2014 Oct;13(10):2361-71.
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