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Chemical Structure : F-901318
CAS No.: 1928707-56-5
Catalog No.: PC-70224Not For Human Use, Lab Use Only.
F-901318 (Olorofim) is a novel antifungal agent that inhibits A. fumigatus DHODH with IC50 of 44 nM.
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|---|---|---|---|
| 5 mg | $398 | In stock | |
| 10 mg | $558 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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F-901318 (Olorofim) is a novel antifungal agent that inhibits A. fumigatus DHODH with IC50 of 44 nM.
F-901318 (Olorofim) shows little inhibition of human DHODH (>100 uM).
F-901318 (Olorofim) displays excellent potency against a broad range of pathogenic filamentous and dimorphic fungi, including Penicillium spp., Coccidiodes immitis, H. capsulatum, Blastomyces dermatitidis, Fusarium spp., and the difficult-to-treat Scedosporium spp.
| M.Wt | 498.562 | |
| Formula | C28H27FN6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide |
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1. Oliver JD, et al. Proc Natl Acad Sci U S A. 2016 Oct 25. pii: 201608304.
2. Wiederhold NP, et al. J Antimicrob Chemother. 2017 Mar 15. doi: 10.1093/jac/dkx065.
3. Buil JB, et al. J Antimicrob Chemother. 2017 Jun 10. doi: 10.1093/jac/dkx177.
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