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F16

Chemical Structure : F16

CAS No.: 36098-33-6

F16 (F-16;Compound F16)

Catalog No.: PC-42131Not For Human Use, Lab Use Only.

A mitochondriotoxic small molecule that selectively inhibits proliferation of mammary epithelial, neu-overexpressing cells, as well as a variety of mouse mammary tumor and human breast cancer cell lines.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A mitochondriotoxic small molecule that selectively inhibits proliferation of mammary epithelial, neu-overexpressing cells, as well as a variety of mouse mammary tumor and human breast cancer cell lines; inhibits oxidative phosphorylation and inducing mitochondrial transmembrane depolarization, induce apoptosis and necrosis in a variety of tumor cells.

Physicochemical Properties

M.Wt 362.2082
Formula C16H15IN2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 31 mg/mL

Chemical Name/SMILES

Pyridinium, 4-[(1E)-2-(1H-indol-3-yl)ethenyl]-1-methyl-, iodide (1:1)

References

1. Fantin VR, et al. Cancer Cell. 2002 Jul;2(1):29-42.

2. Fantin VR, et al. Cancer Res. 2004 Jan 1;64(1):329-36.

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