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Chemical Structure : F44-A13
Catalog No.: PC-22169Not For Human Use, Lab Use Only.
F44-A13 is a highly selective farnesoid X receptor (FXR) antagonist with IC50 of 1.1 uM, with high selectivity over eleven other nuclear receptors.
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F44-A13 is a highly selective farnesoid X receptor (FXR) antagonist with IC50 of 1.1 uM, with high selectivity over eleven other nuclear receptors.
F44-A13 strongly reversed the regulation of FXR target genes and reduced the cholesterol levels in HepG2 cells.
F44-A13 exhibited beneficial effects on reducing cholesterol, triglycerides, and LDL-C levels in C57BL/6 mice.
| M.Wt | 544.71 | |
| Formula | C28H40N4O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xiaodong Dou, et al. Eur J Med Chem. 2024 Apr 5:269:116323.
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