Chemical Structure : FAK PROTAC D4
CAS No.:
2882094-20-2
FAK PROTAC D4
Catalog No.: PC-25158Not For Human Use, Lab Use Only.
FAK PROTAC D4 is a potent and highly selective FAK PROTAC degrader with DC50 of 1.08 nM in PA-1 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
FAK PROTAC D4 is a potent and highly selective FAK PROTAC degrader with DC50 of 1.08 nM in PA-1 cells.
D4-mediated degradation of FAK depends on ligand binding and ubiquitin–proteasome system.
D4 inhibits cell proliferation, colony formation, cell migration, and invasion in vitro.
D4 promotes MHC-I expression and antigen presentation on the surface of tumor cells.
D4 facilitates the activation of antigen-specific CD8+ T cells.
D4 suppresses H22 tumor progression and facilitates CD8+ T cell-mediated immune surveillance.
Physicochemical Properties
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M.Wt
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882.98
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Formula
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C48H50N8O9
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(1-(7-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)heptyl)piperidin-4-yl)-3-methoxy-4-((4-((3-oxo-2,3-dihydro-1H-inden-4-yl)oxy)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)benzamide
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References
1. Wei W, et al. J Med Chem. 2025 Jul 31. doi: 10.1021/acs.jmedchem.5c00921.
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