Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : FDW028
CAS No.: 2768426-49-7
Catalog No.: PC-21002Not For Human Use, Lab Use Only.
FDW028 is a potent and highly selective small-molecule inhibitor of fucosyltransferase 8 (FUT8) with binding KD value of 5.486 uM, displays no affinity against other FUTs, shows potent anti-CRC activities.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
FDW028 is a potent and highly selective small-molecule inhibitor of fucosyltransferase 8 (FUT8) with binding KD value of 5.486 uM, displays no affinity against other FUTs, shows potent anti-CRC activities.
FDW028 exerts potent anti-tumor activities against CRC with IC50 of 5.95 µM and 23.78 µM in SW480 and HCT-8 cells, respectively, significantly represses the migration of SW480 and HCT-8 cells.
FDW028 promotes defucosylation and consequent CMA lysosomal degradation of B7-H3 through CMA pathway.
FDW028 apparently attenuates the expression of both PD-L1 and PD-L2 in CRC cells.
FDW028 attenuates membrane B7-H3 through driving the binding of HSC70 to B7-H3 and consequent autophagolysosomal degradation of B7-H3.
FDW028 (20 mg/kg once the other day, i.v.) prolongs the survival of mice with CRC pulmonary metastases (CRPM).
| M.Wt | 388.48 | |
| Formula | C22H24N6O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-((benzylamino)methyl)-2-((4-ethylbenzyl)amino)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol |
|
1. Wang M, et al. Cell Death Dis. 2023 Aug 3;14(8):495.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
