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Chemical Structure : FEN1-IN-1
CAS No.: 824983-91-7
Catalog No.: PC-62300Not For Human Use, Lab Use Only.
FEN1-IN-1 is a potent, selective Flap Endonuclease-1 (FEN1) inhibitor with IC50 of 11 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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FEN1-IN-1 is a potent, selective Flap Endonuclease-1 (FEN1) inhibitor with IC50 of 11 nM.
FEN1-IN-1 dispalys 1,000-fold specificity over a related endonuclease, xeroderma pigmentosum G (XPG).
FEN1-IN-1 significantly potentiates the action of methyl methanesulfonate (MMS) and temozolamide in a bladder cancer cell line.
| M.Wt | 332.33 | |
| Formula | C15H12N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione |
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1. Exell JC, et al. Nat Chem Biol. 2016 Oct;12(10):815-21.
2. Tumey LN, et al. Bioorg Med Chem Lett. 2005 Jan 17;15(2):277-81.
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