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FGI-104

Chemical Structure : FGI-104

CAS No.:

FGI-104 (FGI104)

Catalog No.: PC-62052Not For Human Use, Lab Use Only.

FGI-104 is a small-molecule inhibitor of filovirus that exhibits potent antiviral activity against of EBOV (EC90=330 nM, ZEBOV) and MARV (EC50=2.5 uM, MARV-Ci67).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

FGI-104 is a small-molecule inhibitor of filovirus that exhibits potent antiviral activity against of EBOV (EC90=330 nM, ZEBOV) and MARV (EC50=2.5 uM, MARV-Ci67); protects mice against a lethal challenge with a mouse-adapted strain of either ZEBOV or MARV-Ravn as a single intraperitoneal dose of 10 mg/kg; reduces viremia and the viral burden in kidney, liver, and spleen tissues in a murine model of ZEBOV infection.

Physicochemical Properties

M.Wt 492.016
Formula C28H30ClN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)-6-[4-(hydroxymethyl)-3-methoxyphenyl]phenol

References

1. Warren TK, et al. Antimicrob Agents Chemother. 2010 May;54(5):2152-9.

2. Haque A, et al. Antimicrob Agents Chemother. 2015 Oct;59(10):5892-902.

3. De Clercq E. Med Res Rev. 2013 Nov;33(6):1249-77.

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