Chemical Structure : FKA-9i
CAS No.:
3060515-85-4
FKA-9i
Catalog No.: PC-27293Not For Human Use, Lab Use Only.
FKA-9i is a potent broad-spectrum anticancer agent, directly binds to leucine-rich PPR motif-containing protein (LRPPRC), Y-box binding protein 1 (YBX1), and ribophorin I (RPN1) with 7.387 μM, 26.82 μM, and 16.52 μM, respectively, reducing their interactions and stability.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
FKA-9i is a potent broad-spectrum anticancer agent, directly binds to leucine-rich PPR motif-containing protein (LRPPRC), Y-box binding protein 1 (YBX1), and ribophorin I (RPN1) with 7.387 μM, 26.82 μM, and 16.52 μM, respectively, reducing their interactions and stability.
FKA-9i impedes cancer progression via LRPPRC-YBX1-RPN1 mediated MAPK signaling pathway.
FKA-9i induces cancer cell cycle arrest, apoptosis, and mitochondrial dysfunction characterized by suppressed oxidative phosphorylation (OXPHOS) and accumulated reactive oxygen species (ROS).
FKA-9i exhibits a synergistic enhancement effect when combined with chemotherapeutic drugs, YBX1 and RPN1 inhibitors, as well as drugs targeting the glycolysis pathway.
Physicochemical Properties
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M.Wt
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660.66
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Formula
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C30H26F2N2O9S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2H-1-Benzopyran-8-sulfonamide, N-(4-fluorophenyl)-2-[3-[[(4-fluorophenyl)amino]sulfonyl]-4-methoxyphenyl]-3,4-dihydro-5,7-dimethoxy-4-oxo-
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References
1. Rui Wu, et al. Bioorg Chem. 2026 Mar:170:109425.
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