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Chemical Structure : FKBP12 PROTAC dTAG-7
CAS No.: 2064175-32-0
Catalog No.: PC-35858Not For Human Use, Lab Use Only.
FKBP12 PROTAC dTAG-7 (dTAG-7) is a cell-permeable heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN, selectively degrade FKBP12F36V in a CRBN-dependent manner in cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $218 | In stock | |
| 5 mg | $388 | In stock | |
| 10 mg | $598 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote |
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FKBP12 PROTAC dTAG-7 (dTAG-7) is a cell-permeable heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN, selectively degrade FKBP12F36V in a CRBN-dependent manner in cells.
dTAG-7 causes rapid degradation of nuclear and cytoplasmic FKBP12F36V fusion chimeras.
| M.Wt | 1210.341 | |
| Formula | C63H79N5O19 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1R)-3-(3,4-dimethoxyphenyl)-1-(2-((19-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2,18-dioxo-7,10,13-trioxa-3,17-diazanonadecyl)oxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate |
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1. Nabet B, et al. Nat Chem Biol. 2018 May;14(5):431-441.
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