Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : FL-18
Catalog No.: PC-72870Not For Human Use, Lab Use Only.
FL-18 (p97 inhibitor FL-18) is is the first small-molecule covalent inhibitor of VCP/p97 AAA ATPase with IC50 of 59.3 nM, capable of covalent engagement of p97 with proteome-wide selectivity.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
FL-18 (p97 inhibitor FL-18) is is the first small-molecule covalent inhibitor of VCP/p97 AAA ATPase with IC50 of 59.3 nM, capable of covalent engagement of p97 with proteome-wide selectivity.
FL-18 showed better inhibition potency than NMS-873, a well-known p97 inhibitor.
FL-18 covalently modified C522 residue in p97 and showed potent enzymatic inhibition.
FL-18 showed potent inhibition towards U87MG glioma cancer cells (IC50=31 nM).
FL-18 inhibited the p97 activity and induced aggregation of ubiquitinated proteins in U87MG cells.
| M.Wt | 375.428 | |
| Formula | C22H21N3O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Zi Ye, et al. Acta Pharm Sin B. 2022 Feb;12(2):982-989.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
