| Cat. No. |
Product Name |
Information |
| PC-27882 |
UP163
VCP activator
|
UP163 is a small molecule allosteric activator of VCP ATPase activity with EC50 of 9.0 uM and Emax of 204%, exhibits ATPase domain–specific effects, enhances clearance of intranuclear TDP-4FL inclusions in cells expressing GFP-TDP-4FL. |
| PC-27881 |
KB3409
VCP activator
|
KB3409 is an allosteric activator of valosin-containing protein (VCP/p97), directly binds VCP and reticulocalbin-2 (RCN2), enhancing VCP ATPase activity and promoting autophagic flux. |
| PC-27077 |
GND-135
VCP/p97 inhibitor
|
GND-135 is a potent, cell-permeable, and orally bioavailable inhibitor of VCP/p97 AAA ATPase with IC50 of <10 nM. |
| PC-26296 |
NMS-859
VCP/p97 inhibitor
|
NMS-859 is a covalent small-molecule inhibitor of VCP/p97 AAA+ ATPase with IC50 of 0.37 uM, covalently modifies VCP on the active site Cys522 and blocks ATP binding. |
| PC-26295 |
UTE-156
VCP/p97 inhibitor
|
UTE-156 is a potent, covalent small-molecule inhibitor of VCP/p97 AAA+ ATPase with IC50 of 10 nM, modifies Cys522 within the D2 ATPase domain of VCP. |
| PC-25308 |
Eeyarestatin I
VCP inhibitor, ERAD inhibitor, Sec61 inhibitor
|
Eeyarestatin I (Eeyarestatin 1, ESI, ES1) is a potent endoplasmic reticulum-associated protein degradation (ERAD) inhibitor, targets the p97-associated deubiquitinating process (PAD) and inhibits atx3-dependent deubiquitination, inhibits Sec61 translocon. |
| PC-24320 |
VPS4 inhibitor 4-107
VPS4 inhibitor
|
VPS4 inhibitor 4-107 is a DBeQ derivative and vacuolar protein sorting 4 (VPS4) AAA-ATPase inhibitor (IC50=3.7 uM, VPS4B), inhibits VPS4 ATPase activity, induces CASP8-mediated apoptosis. |
| PC-22572 |
UP109
VCP activator
|
UP109 is a small molecule activator of VCP ATPase activity with EC50 of 24.7 uM, Emax of 197%, activates VCP primarily by increasing D2 ATPase activity. |
| PC-21286 |
VCP Activator 1
VCP/p97 activator
|
VCP Activator 1 (VA1) is a small molecule allosteric activator of valosin-containing protein (VCP)/p97, dose-dependently stimulates VCP ATPase activity up to 3-fold (EC50= 4 uM). |
| PC-49108 |
NW1030
p97 modulator
|
NW1030 is a small molecule that target the regulatory domain of VCP/p97, increases the degradation of a p97-dependent reporter, does not affect the main catalytic domain of p97. |
| PC-49107 |
NW1028
p97 modulator
|
NW1028 is a small molecule that target the regulatory domain of VCP/p97, inhibits the degradation of a p97-dependent reporter, does not affect the main catalytic domain of p97. |
| PC-38720 |
OSSL_325096
p97/VCP inhibitor
|
OSSL_325096 is a novel potent small mlolecule p97/VCP inhibitor, suppresses cell proliferation and induces ER stress and apoptotic cell death in MM cell lines (IC50=0.1-0.5 uM). |
