Tivumecirnon (FLX475) | CCR4 antagonist

Chemical Structure : FLX475

CAS No.: 2174938-78-2

Catalog No.: PC-61981Not For Human Use, Lab Use Only.

Tivumecirnon (FLX475) is a novel potent, selective CCR4 antagonist, blocks the migration of regulatory T cells (Treg) specifically into tumors.

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Biological Activity

Tivumecirnon (FLX475) is a novel potent, selective CCR4 antagonist, blocks the migration of regulatory T cells (Treg) specifically into tumors.

M.Wt	543.42
Formula	C24H27Cl2F3N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((R)-3-(1-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)azetidin-3-yl)piperidin-1-yl)ethan-1-ol

1. Adam Grant, et al. Cancer Res 15 March 2024; 84 (6_Supplement): 2485.