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Chemical Structure : FMP-201300
Catalog No.: PC-21232Not For Human Use, Lab Use Only.
FMP-201300 is a potent, selective and allosteric inhibitor of the unique valine gatekeeper mutants of IP6K1 and IP6K2 with IC50 of 114/190 nM for IP6K1 L210V and IP6K2 L210V mutants respectively.
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FMP-201300 is a potent, selective and allosteric inhibitor of the unique valine gatekeeper mutants of IP6K1 and IP6K2 with IC50 of 114/190 nM for IP6K1 L210V and IP6K2 L210V mutants respectively.
FMP-201300 binds to an allosteric pocket adjacent to the ATP binding site.
FMP-201300 shows no known inhibitory activities against other biological targets and does not display any recognized PAINS motifs.
FMP-201300 is neither redox-active, nor cytotoxic, against HEK293 or HepG2 cell lines at a concentration of 10 µM.
| M.Wt | 572.49 | |
| Formula | C31H16N4O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Aguirre T, et al. Elife. 2023 Oct 16;12:RP88982.
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