Catalog No.: PC-25800Not For Human Use, Lab Use Only.
FN-1501 (FN1501) is a potent FLT3 and CDK inhibitor with IC50 of 0.27 nM, 2.47 nM, 0.85 nM and 1.96 nM for FLT3, CDK2/cyclin A, CDK4/cyclin D1, and CDK6/cyclin D1 respectively, induces collapsin response mediator protein 2 (CRMP2) dephosphorylation in breast cancer cells.
FN-1501 (FN1501) is a potent FLT3 and CDK inhibitor with IC50 of 0.27 nM, 2.47 nM, 0.85 nM and 1.96 nM for FLT3, CDK2/cyclin A, CDK4/cyclin D1, and CDK6/cyclin D1 respectively, induces collapsin response mediator protein 2 (CRMP2) dephosphorylation in breast cancer cells. FN-1501 exhibits potent inhibitory activities on all 60 cancer cell lines with GI50 of <0.5 uM. FN-1501 shows significant antiproliferative activities against MV4-11 cells with IC50 of 8 nM. FN-1501 (0-1 uM) significantly decreased the phosphorylation of FLT3 and that of its downstream mediators STAT5, ERK, and AKT in MV4-11 cells. FN-1501 at 15 (mg/kg)/d induced tumor regression MV4-11-xenograft model.
