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Chemical Structure : FOXM1 inhibitor NB-55
Catalog No.: PC-20009Not For Human Use, Lab Use Only.
FOXM1 inhibitor NB-55 is a small molecule inhibitor of transcription factor FOXM1 with Ki value of 230 nM and IC50 of 1.24 uM, bind directly to FOXM1 and alter its proteolytic sensitivity, reduces the cellular level of FOXM1 protein.
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FOXM1 inhibitor NB-55 is a small molecule inhibitor of transcription factor FOXM1 with Ki value of 230 nM and IC50 of 1.24 uM, bind directly to FOXM1 and alter its proteolytic sensitivity, reduces the cellular level of FOXM1 protein.
NB-55 suppresses breast cancer cell proliferation and cell cycle progression and increase apoptosis.
NB-55 decreases expression of FOXM1-regulated genes and suppress gene ontologies under FOXM1 regulation.
| M.Wt | 504.16 | |
| Formula | C33H42ClNO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Parama Dey, et al. Cancers (Basel). 2020 Sep 19;12(9):2677.
2. Ipshita Nandi, et al. J Clin Invest. 2023 Apr 3;133(7):e162324.
3. Yvonne Ziegler, et al. NPJ Breast Cancer. 2019 Nov 29;5:45.
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