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Chemical Structure : FR054
CAS No.: 10378-06-0
Catalog No.: PC-49557Not For Human Use, Lab Use Only.
FR054 (FR-054) is a specific small molecule inhibitor of hexosamine biosynthetic pathway (HBP) enzyme N-Acetylglucosamine-phosphate Mutase (PGM3), shows a remarkable anti-breast cancer effect.
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FR054 (FR-054) is a specific small molecule inhibitor of hexosamine biosynthetic pathway (HBP) enzyme N-Acetylglucosamine-phosphate Mutase (PGM3), shows a remarkable anti-breast cancer effect.
FR054 enhanced the stability of PGM3 protein in a dose-dependent manner and with a more potent binding than the natural substrate GlcNAc-6-P.
FR054 induced an early proliferation arrest followed by a marked cell death increase in breast cancer cells.
FR054 (250 μM, 24 h) treatment efficiently affected both N- and O-glycosylation levels in MDA-MB-231 cells.
FR054 reduced MDA-MB-231 cell adhesion, migration, and integrin β1 membrane localization, induced ER stress and a ROS-dependent apoptotic cell death.
FR054 (1000 mg/kg, 10% DMSO) administered in single dose reduced tumor growth in nude mice xenograft model of TNBC cells MDA-MB-231.
| M.Wt | 329.30 | |
| Formula | C14H19NO8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-d-glucopyrano)-[2,1-d]-2-oxazoline |
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1. Ricciardiello F, et al. Cell Death Dis. 2018 Mar 7;9(3):377.
2. Ricciardiello F, et al. Oncogene. 2020 May;39(20):4103-4117.
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