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Chemical Structure : FSC 231
Catalog No.: PC-62059Not For Human Use, Lab Use Only.
FSC 231 (FSC231) is the first, cell-permeable small-molecule inhibitor of PICK1 PDZ domain with Kd of 10.1 uM.
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FSC 231 (FSC231) is the first, cell-permeable small-molecule inhibitor of PICK1 PDZ domain with Kd of 10.1 uM; inhibits the interaction between GluR2 and PICK1, accelerates recycling of pHluorin-tagged GluR2 in hippocampal neurons; blocks the expression of both long-term depression and long-term potentiation in rats and murine hippocampal neurons.
| M.Wt | 313.134 | |
| Formula | C13H10Cl2N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Thorsen TS, et al. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):413-8.
2. Qiu CY, et al. J Neuroinflammation. 2012 May 29;9:108.
3. Herbert LM, et al. Am J Physiol Cell Physiol. 2016 Mar 1;310(5):C390-400.
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