Catalog No.: PC-27442Not For Human Use, Lab Use Only.
FSG67 is a small molecule mitochondrial glycerol-3-phosphate acyltransferase (mitochondrial GPAT, GPAM) inhibitor with IC50 30.2 μM for total mitochondrial GPAT and 42.1 μM for GPAT1.
FSG67 is a small molecule mitochondrial glycerol-3-phosphate acyltransferase (mitochondrial GPAT, GPAM) inhibitor with IC50 30.2 μM for total mitochondrial GPAT and 42.1 μM for GPAT1. FSG67 reduces acylglyceride synthesis in 3T3-L1 adipocytes, has IC50 of 33.9 μM for cellular triglyceride synthesis and 36.3 μM for phosphatidylcholine synthesis. Acute FSG67 treatment (20 mg/kg ip) produces weight loss and decreases food consumption in lean and DIO mice. Chronic FSG67 decreases the size of white adipocytes and resolves hepatic steatosis in DIO mice, reduces food consumption and body weight. FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling.
Physicochemical Properties
M.Wt
327.44
Formula
C16H25NO4S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-(Nonylsulfonamido)benzoic acid
References
1. Clemens MM, et al. Food Chem Toxicol. 2019 Mar;125:279-288.
2. Kuhajda FP, et al. Am J Physiol Regul Integr Comp Physiol. 2011 Jul;301(1):R116-30.
3. Irifune H, et al. Cancer Sci. 2023 Aug;114(8):3247-3258.
