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Chemical Structure : FT206
CAS No.: 2278274-34-1
Catalog No.: PC-38173Not For Human Use, Lab Use Only.
FT206 (FT-206, FT3951206, CRT0511973) is a potent, selectivel inhibitor of USP28 with a remarkable USP28/25 selectivity.
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|---|---|---|---|
| 5 mg | $258 | In stock | |
| 25 mg | $598 | In stock | |
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| 200 mg | Get quote | ||
| 1 g | Get quote |
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FT206 (FT-206, FT3951206, CRT0511973) is a potent, selectivel inhibitor of USP28 with a remarkable USP28/25 selectivity.
FT206 interferes with USP28/25 probe labelling (USP-ABP versus USP) in LSCC H520 cell extracts with EC50 of 0.3-1 uM.
USP28 inhibition causes apoptotic cell death of LSCC tumour cells.
FT206 also resulted in reduced Δp63, c-JUN, and c-MYC protein levels, causes dramatic regression of human LSCC xenograft tumours in vivo.
| M.Wt | 447.601 | |
| Formula | C25H29N5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-[(2S)-6-(3,8-diazabicyclo[3.2.1]oct-3-yl)-1,2,3,4-tetrahydro-2-naphthalenyl]-6-methyl- |
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1. E Josue Ruiz, et al. Elife. 2021 Oct 12;10:e71596.
2. Jonathan D Wrigley, et al. ACS Chem Biol. 2017 Dec 15;12(12):3113-3125.
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