Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : FTBMT
CAS No.: 1358575-02-6
Catalog No.: PC-35386Not For Human Use, Lab Use Only.
FTBMT is a novel selective GPR52 agonist of GPR52, increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50 of 7.03, 6.85, and 6.87M, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 25 mg | $368 | In stock | |
| 100 mg | $758 | In stock | |
| 500 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
FTBMT (TP 024) is a novel selective GPR52 agonist of GPR52, increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50 of 7.03, 6.85, and 6.87M, respectively.
FTBMT does not show significant inhibition or stimulation in a panel of 98 other targets, including receptors, ion channels, and enzymes.
FTBMT elevates the levels of cAMP (pEC50=6.82) and phosho-CREB, which increased the expression of downstream CREB target genes, c-fos and Egr-2.
FTBMT inhibits MK-801-induced hyperactivity, shows antipsychotic and recognitive properties without causing catalepsy in rodents.
| M.Wt | 392.35 | |
| Formula | C19H16F4N4O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-(3-(3-Fluoro-5-(trifluoromethyl)benzyl)-5-methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide |
|
1. Nishiyama K, et al. J Pharmacol Exp Ther. 2017 Nov;363(2):253-264.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
