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Chemical Structure : Faldaprevir
Catalog No.: PC-60953Not For Human Use, Lab Use Only.
A potent, selective noncovalent competitive inhibitor of HCV NS3/4A protease with Ki of 2.6 and 2.0 nM for GT1a and 1b NS3-NS4A protease, respectively.
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A potent, selective noncovalent competitive inhibitor of HCV NS3/4A protease with Ki of 2.6 and 2.0 nM for GT1a and 1b NS3-NS4A protease, respectively; also shows Ki of 2 to 230 nM for HCV GT2 to 6, potently inhibits HCV RNA replication in vitro of 6.5 and 3.1 nM in genotype 1a and 1b replicon assays, respectively; possesses good ADME profile in vitro and pharmacokinetics in vivo.
HCV Infection
Phase 2 Clinical
| M.Wt | 869.829 | |
| Formula | C40H49BrN6O9S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Llinàs-Brunet M, et al. J Med Chem. 2010 Sep 9;53(17):6466-76.
2. White PW, et al. Antimicrob Agents Chemother. 2010 Nov;54(11):4611-8.
3. Manns MP, et al. J Hepatol. 2011 Jun;54(6):1114-22.
4. Zeuzem S, et al. Gastroenterology. 2011 Dec;141(6):2047-55; quiz e14.
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