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Chemical Structure : Feeblin
Catalog No.: PC-21265Not For Human Use, Lab Use Only.
Feeblin (SLC15A4 inhibitor C5) is a small molecule inhibitor of the proinflammatory TLR7/8/9-IRF5 pathway (IC50=1.6 uM) by disrupting the SLC15A4-TASL adapter module, Feeblin is an IRF5 pathway-specific inhibitor.
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Feeblin (SLC15A4 inhibitor C5) is a small molecule inhibitor of the proinflammatory TLR7/8/9-IRF5 pathway (IC50=1.6 uM) by disrupting the SLC15A4-TASL adapter module, Feeblin is an IRF5 pathway-specific inhibitor.
Feeblin (SLC15A4 inhibitor C5) displays specific inhibition of IRF5, shows no or little activity on STING, NOD1/2 or RIG-like helicase pathways.
Feeblin (SLC15A4 inhibitor C5) significantly reduces IRF5 nuclear translocation, without affecting the activation of NF-κB p65.
Feeblin (SLC15A4 inhibitor C5) locks SLC15A4 in a TASL binding-incompetent lysosomal outward-open conformation.
| M.Wt | 431.58 | |
| Formula | C27H33N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Andras Boeszoermenyi, et al. Nat Commun. 2023 Oct 20;14(1):6626.
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