Ferrostatin-1 (Fer-1) is a potent ferroptosis inhibitor with IC50 of 33 nM, inhibits erastin-induced ferroptosis in HT-1080 cells with EC50 of 60 nM.
Ferrostatin-1 (Fer-1) prevents erastin-induced accumulation of cytosolic and lipid ROS.
Ferrostatin-1 (Fer-1) does not inhibit ERK phosphorylation or arrest the proliferation of HT-1080 cells.
Physicochemical Properties
M.Wt
262.353
Formula
C15H22N2O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
ethyl 3-amino-4-(cyclohexylamino)benzoate
References
1. Devisscher L, et al. J Med Chem. 2018 Oct 25. doi: 10.1021/acs.jmedchem.8b01299.
