| Cat. No. |
Product Name |
Information |
| PC-28364 |
THTZO4c
Ferroptosis inhibitor
|
THTZO4c is a potent nonclassical radical-trapping antioxidant and ferroptosis inhibitor with EC50 of 30 nM, effectively suppresses erastin-induced ferroptosis in HT22 cells, as well as RSL3-induced ferroptosis in HSC-LX2, and MIA PaCa-2 cells. |
| PC-28363 |
THTZO4a
Ferroptosis inhibitor
|
THTZO4a is a potent nonclassical radical-trapping antioxidant and ferroptosis inhibitor with EC50 of 92 nM, effectively suppresses erastin-induced ferroptosis in HT22 cells, as well as RSL3-induced ferroptosis in HSC-LX2, and MIA PaCa-2 cells. |
| PC-28285 |
ACXT-3102
Ferroptosis inducer, xCT inhibitor
|
ACXT-3102 (SW V-49) is a cancer-specific drug conjugate and ferroptosis inducer consisting of a pro-apoptotic sigma-2 ligand as a delivery moiety (SV119), linked to an inhibitor of the cystine antiporter xCT (des-methyl Erastin, dm-Erastin), exhibits potent, targeted therapeutic for pancreatic cancer cells. |
| PC-27626 |
4-Hydroxynonenal
ALDH2 substrate, Ferroptosis inducer
|
4-Hydroxynonenal (4-HNE) is a lipoperoxidation-derived aldehyde and ALDH2 substrate that promotes oxidative stress, induces ferroptosis, and aggravates myocardial injury, directly evokes myocyte ferroptosis by interacting with GPX4 and deubiquitinase OTUD5 at cysteine residues, leading to increased ubiquitination and degradation of GPX4. |
| PC-26804 |
FXT-003
Ferroptosis inhibitor
|
FXT-003 (FXT003) is a highly potent, effective, orally bioavailable next-generation ferroptosis inhibitor with IC50 of 11.7 nM in HT-1060 cells. |
| PC-26803 |
FXT-002
Ferroptosis inhibitor
|
FXT-002 (FXT002) is a highly potent, effective, orally bioavailable next-generation ferroptosis inhibitor with IC50 of 6.91 nM in HT-1060 cells, shows dual radical and iron-trapping activity. |
| PC-26734 |
Sulfasalazine
SLC7A11/xCT inhibitor, Ferroptosis inducer
|
Sulfasalazine (NSC 667219) is a disease-modifying antirheumatic drug used to treat arthritis and ankylosing spondylitis, is a SLC7A11/xc(-) cystine/glutamate antiporter (xCT) inhibitor, has anti-leukemic activity against primary AML samples, is also a ferroptosis inducer. |
| PC-24821 |
PKUMDL-LC-102
GPX4 activator
|
PKUMDL-LC-102 is a selective, allosteric small molecule GPX4 activator (150% activation at 39.2 μM), shows no activity against COX-1, COX-2, mPGES-1, 5-LOX, LTA4H, 12-LOX, and 15-LOX. |
| PC-24567 |
CuATSM
Ferroptosis inhibitor, SOD1 modulator
|
CuATSM is orally available brain-penetrant copper compound that scavenges free radicals, inhibits lipid peroxidation and ferroptosis, stabilises various ALS-associated variants of the SOD1 protein, reducing misfolding and toxicity. |
| PC-24537 |
DEL-I25
GPX4 R152H activator
|
DEL-I25 is a selective, small molecule activator of GPX4 R152H variant, selectively binds to GPX4 R152H (MST binding KD, 2 uM), restores GPX4R152H enzyme activity, and specifically rescues patient-derived lymphoblast cells. |
| PC-24078 |
Ferfluor-1
Ferroptosis inhibitor
|
Ferfluor-1 is a potent, selective ferroptosis inhibitor, rescues ferroptotic cell death on HT1080 cells with EC50 of 57 nM, also is a specific ferroptosis photoluminescence imaging probe. |
| PC-22833 |
NCOA4-FTH1 inhibitor 9a
NCOA4-FTH1 inhibitor
|
NCOA4-FTH1 inhibitor 9a is a new ferroptosis inhibitor through disrupting the NCOA4-FTH1 protein-protein interaction, reduces intracellular ferrous iron, inhibits Erastin-induced ferroptosiswith EC50 of 0.29 μM in HT22 cells. |
