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Chemical Structure : Fevipiprant
CAS No.: 872365-14-5
Catalog No.: PC-45075Not For Human Use, Lab Use Only.
Fevipiprant (NVP-QAW039, QAW-039) is a potent, selective, slowly dissociating CRTh2 antagonist with Kd of 1.14 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $598 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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Fevipiprant (NVP-QAW039, QAW-039) is a potent, selective, slowly dissociating CRTh2 antagonist with Kd of 1.14 nM.
NVP-QAW039 shows a half-life of 14.4 minutes, >7-fold slower than AZD-1981.
NVP-QAW039 inhibits PGD2-stimulated human eosinophil shape change, retains its potency in the whole-blood shape-change assay relative to the isolated shape change assays.
NVP-QAW039 also is a potent inhibitor of PGD2-induced cytokine release in human Th2 cells.
| M.Wt | 426.4095 | |
| Formula | C19H17F3N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
1H-Pyrrolo[2,3-b]pyridine-3-acetic acid, 2-methyl-1-[[4-(methylsulfonyl)-2-(trifluoromethyl)phenyl]methyl]- |
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1. Sykes DA, et al. Mol Pharmacol. 2016 May;89(5):593-605.
2. Sandham DA, et al. ACS Med Chem Lett. 2017 Apr 25;8(5):582-586.
3. Bateman ED, et al. Eur Respir J. 2017 Aug 24;50(2). pii: 1700670.
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