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Chemical Structure : Firsocostat
CAS No.: 1434635-54-7
Catalog No.: PC-61377Not For Human Use, Lab Use Only.
Firsocostat (ND-630, NDI-010976, GS-0976) is a highly potent, selective inhibitor of acetyl-CoA carboxylase (ACC) with IC50 of 2.1 and 6.1 nM for isozymes ACC1 and ACC2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Firsocostat (ND-630, NDI-010976, GS-0976) is a highly potent, selective inhibitor of acetyl-CoA carboxylase (ACC) with IC50 of 2.1 and 6.1 nM for isozymes ACC1 and ACC2, respectively.
Firsocostat (ND-630) displays no activity against 101 enzymes, receptors, growth factors, transporters, and ion channels at 10 uM.
Firsocostat (ND-630) reduces hepatic steatosis, improves insulin sensitivity, reduces weight gain without affecting food intake, and favorably affects dyslipidemia in DIO mice.
| M.Wt | 569.629 | |
| Formula | C28H31N3O8S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[1-{(2R)-2-(2-methoxyphenyl)-2-[(oxan-4-yl)oxy]ethyl}-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl]-2-methylpropanoic acid |
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1. Harriman G. et al. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1796-805.
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