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Chemical Structure : Foretinib
CAS No.: 849217-64-7
Catalog No.: PC-42535Not For Human Use, Lab Use Only.
Foretinib (XL880, GSK1363089, GSK089, EXEL-2880) is a potent, multikinase inhibitor that inhibits c-Met and VEGFR, also KIT, Flt-3, PDGFRβ, and Tie-2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Foretinib (XL880, GSK1363089, GSK089, EXEL-2880) is a potent, multikinase inhibitor that inhibits c-Met and VEGFR, also inhibits KIT, Flt-3, PDGFRβ, and Tie-2.
Foretinib inhibits HGFR family tyrosine kinases with IC50 of 0.4 nM for Met and 3 nM for Ron, also inhibits KDR, Flt-1, and Flt-4 with IC50 of 0.9, 6.8, and 2.8 nM, respectively.
Foretinib exhibits modest activity against FGFR1 and EGFR, no activity against 50 serine/threonine kinases, including CDKs and PKC isoforms.
Foretinib inhibits cellular HGF-induced Met phosphorylation and VEGF-induced ERK phosphorylation and prevents both HGF-induced responses of tumor cells and HGF/VEGF-induced responses of endothelial cells.
Foretinib exhibits significant inhibition of tumor burden in animal model of lung metastasis.
| M.Wt | 632.6537 | |
| Formula | C34H34F2N4O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 38 mg/mL |
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| Chemical Name/SMILES |
1,1-Cyclopropanedicarboxamide, N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)- |
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1. Qian F, et al. Cancer Res. 2009 Oct 15;69(20):8009-16.
2. Liu L, et al. Cancer Res. 2009 Sep 1;69(17):6871-8.
3. Eder JP, et al. Clin Cancer Res. 2010 Jul 1;16(13):3507-16.
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