Chemical Structure : Forvisirvat
CAS No.:
2135638-06-9
Forvisirvat
(SP-624, SP624)
Catalog No.: PC-25052Not For Human Use, Lab Use Only.
Forvisirvat (SP-624) is a selective, orally active sirtuin 6 (SIRT6) activator.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Forvisirvat (SP-624) is a selective, orally active sirtuin 6 (SIRT6) activator.
SP-624 activates SIRT6 deacetylation of histone peptides and deacetylation of H3K9 and H3K18 in intact nucleosomes.
SP-624 is active in multiple animal models used to predict efficacy for depression in humans, including tests in adrenocorticotropic hormone‐treated mice and olfactory bulbectomized rats.
SP-624 also prevents cognitive deficits induced by scopolamine (anticholinergic) or phencyclidine (N-methyl-D-aspartate antagonist) in the novel object recognition test and suppressed excessive cytokine release in animal models.
Physicochemical Properties
|
M.Wt
|
404.80
|
|
Formula
|
C19H17ClN2O6
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(2S,6'R)-7-chloro-2',4-dimethoxy-6'-methyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-3H-spiro[benzofuran-2,1'-cyclohexan]-2'-ene-3,4'-dione
|
References
1. Greg Rigdon, et al. Clin Pharmacol Drug Dev. 2025 Jan;14(1):18-25.
2. Patent WO2024168215 A1.
Contact Us
sales@probechem.com
