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Fosdagrocorat

Chemical Structure : Fosdagrocorat

CAS No.: 1044535-58-1

Fosdagrocorat (PF 04171327)

Catalog No.: PC-61849Not For Human Use, Lab Use Only.

Fosdagrocorat (PF 04171327) is an orally available, potential dissociated agonist of the glucocorticoid receptor (GR) for the treatment of rheumatoid arthritis, the phosphate ester prodrug of PF-00251802 (dagrocorat)..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Fosdagrocorat (PF 04171327) is an orally available, potential dissociated agonist of the glucocorticoid receptor (GR) for the treatment of rheumatoid arthritis, the phosphate ester prodrug of PF-00251802 (dagrocorat).

Rheumatoid Arthritis

Phase 2 Discontinued

Physicochemical Properties

M.Wt 574.537
Formula C29H30F3N2O5P
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2R,4aS,10aR)-4a-benzyl-7-((2-methylpyridin-3-yl)carbamoyl)-2-(trifluoromethyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl dihydrogen phosphate

References

1. Stock T, et al. Int J Rheum Dis. 2017 Aug;20(8):960-970.

2. Miyoshi S, et al. Int J Clin Pharmacol Ther. 2016 Dec;54(12):966-976.

3. Ripp SL, et al. Clin Pharmacol Drug Dev. 2017 Nov 7. doi: 10.1002/cpdd.411.

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