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Fumonisin B1

Chemical Structure : Fumonisin B1

CAS No.: 116355-83-0

Fumonisin B1 (FB1)

Catalog No.: PC-61424Not For Human Use, Lab Use Only.

A mycotoxin produced from F. moniliforme, and an inhibitor of ceramide synthase (sphingosine N-acyltransferase/CerS).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A mycotoxin produced from F. moniliforme, and an inhibitor of ceramide synthase (sphingosine N-acyltransferase/CerS); attenuates the response of P388D1 cells to PAF and LPS by inhibiting ceramide formation; blocks the apoptotic response of HaCaT cells to the antiproliferative drug hexadecylphosphocholine, through inhibition of ceramide production; alteres cell morphology and decreases in cell proliferation in Swiss 3T3 cells.

Physicochemical Properties

M.Wt 721.8
Formula C34H59NO15
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2R,2’R)-1,2,3-propanetricarboxylic acid, 1,1’-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-amino-4,9,11-trihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl] ester

References

1. Merrill AH Jr, et al. J Biol Chem. 1993 Dec 25;268(36):27299-306.

2. Balsinde J, et al. J Biol Chem. 1997 Aug 15;272(33):20373-7.

3. Meivar-Levy I, et al. J Biol Chem. 1999 Feb 19;274(8):4607-12.

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