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Chemical Structure : Fumosorinone
Catalog No.: PC-61271Not For Human Use, Lab Use Only.
Fumosorinone is a novel potent, selective protein tyrosine phosphatase SHP2 inhibitor with IC50 of 6.31 uM.
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Fumosorinone is a novel potent, selective protein tyrosine phosphatase SHP2 inhibitor with IC50 of 6.31 uM.
Fumosorinone shows little to no inhibition toward other human PTPs (2-7 fold over PTP1B, TCPTP and SHP1).
Fumosorinone inhibits Shp2-dependent activation of the Ras/ERK signal pathway downstream of EGFR, and interrupts EGF-induced Gab1-Shp2 association.
Fumosorinone shows little effects on the Shp2-independent ERK1/2 activation induced by PMA or oncogenic Ras.
Fumosorinone down-regulates Src activation, inhibits phosphorylation of Paxillin and prevents tumor cell invasion.
Fumosorinone shows anti-diabetic effect in diabetic KKAy mice.
| M.Wt | 477.601 | |
| Formula | C29H35NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen C, et al. Sci Rep. 2015 Dec 2;5:17626.
2. Liu L, et al. Fungal Genet Biol. 2015 Aug;81:191-200.
3. Liu ZQ, et al. Toxicol Appl Pharmacol. 2015 May 15;285(1):61-70.
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