Fusicoccin (Fusicoccin A) | 14-3-3 modulator

Chemical Structure : Fusicoccin

CAS No.: 20108-30-9

Fusicoccin (Fusicoccin-A, Fusicoccin A, FC-A)

Catalog No.: PC-61233Not For Human Use, Lab Use Only.

Fusicoccin (Fusicoccin A) is a fungal pytotoxin and small-molecule stabilizer of 14-3-3 protein-protein interactions that stabilizes the complex between 14-3-3 and the stress response regulator GCN1.

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1 mg	$798	In stock
2 mg	$1280	In stock
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Biological Activity

Fusicoccin (Fusicoccin A) is a fungal pytotoxin and small-molecule stabilizer of 14-3-3 protein-protein interactions that stabilizes the complex between 14-3-3 and the stress response regulator GCN1.
Fusicoccin (Fusicoccin A) induces GCN1 turnover and neurite outgrowth, stimulates axon growth in vitro and regeneration in vivo.
Fusicoccin (Fusicoccin A) stabilizes the interaction between 14-3-3 and CFTR by selectively interacting with a secondary binding motif of CFTR (pS753).

Physicochemical Properties

M.Wt	680.82
Formula	C36H56O12
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	α-D-Glucopyranoside, (1S,4R,5R,6R,6aS,9S,10aR)-3-[(1S)-2-(acetyloxy)-1-methylethyl]-1,2,4,5,6,6a,7,8,9,10a-decahydro-1,5-dihydroxy-9-(methoxymethyl)-6,10a-dimethyldicyclopenta[a,d]cycloocten-4-yl 6-O-(1,1-dimethyl-2-propenyl)-, 3-acetate (9CI)

References

1. Kaplan A, et al. Neuron. 2017 Mar 8;93(5):1082-1093.e5.

2. Stevers LM, et al. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1152-61.

Fusicoccin (Fusicoccin-A, Fusicoccin A, FC-A)

Biological Activity

Physicochemical Properties

References

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