G2A antagonist 65

Chemical Structure : G2A antagonist 65

Catalog No.: PC-27319Not For Human Use, Lab Use Only.

G2A antagonist 65 is a potent, selective G protein coupled receptor 132 (GPR132 or G2A) antagonist with IC50 of 0.69 uM, prevents the 9-HODE-mediated sensitization of capsaicin-induced TRPV1 responses in primary sensory neurons.

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Biological Activity

Physicochemical Properties

M.Wt	419.26
Formula	C19H16Cl2N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3,4-Dichlorophenyl)-2-(2-(3,5-dimethylisoxazol-4-yl)acetamido)isonicotinamide

References

1. Victor Hernandez-Olmos, et al. J Med Chem. 2026 Jun 25;69(12):14309-14332.

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G2A antagonist 65

Biological Activity

Physicochemical Properties

References

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