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Chemical Structure : G3BP inhibitor a
Catalog No.: PC-21744Not For Human Use, Lab Use Only.
G3BP inhibitor a (G3Ia) is a specific, peptide mimetic inhibitor of RNA-binding proteins G3BP1/2 with SPR Kd value of 0.54 uM, blcoks the association of G3BP with its binding partners and inhibits condensation of G3BP both in vitro and in live cells.
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G3BP inhibitor a (G3Ia) is a specific, peptide mimetic inhibitor of RNA-binding proteins G3BP1/2 with SPR Kd value of 0.54 uM, blcoks the association of G3BP with its binding partners and inhibits condensation of G3BP both in vitro and in live cells.
G3BP inhibitor a (G3Ia) binds the NTF2L domain of G3BP1. disrupt in vitro condensation of RNA, G3BP1, and caprin 1.
G3BP inhibitor a (G3Ia) (50 uM) inhibits stress granule formation in HeLa cells about 72%.
G3BP inhibitor a (G3Ia) (50 uM) reduces eIF3η, PABPC1, and FXR1 puncta, indicating disassembly of stress granules beyond simple extraction of G3BP1, does not influence the rate of translation in cells.
G3BP inhibitor a (G3Ia) prevents the formation of stress granules and dissolves preformed stress granules in human iPSC-derived neurons, dissolves stress granules formed in response to expression of a disease-causing VCP mutant.
| M.Wt | 713.89 | |
| Formula | C38H56FN5O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Freibaum BD, et al. J Cell Biol. 2024 Mar 4;223(3):e202308083.
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