Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : G3BP inhibitor b
Catalog No.: PC-21745Not For Human Use, Lab Use Only.
G3BP inhibitor b (G3Ib) is a specific, peptide mimetic inhibitor of RNA-binding proteins G3BP1/2 with SPR Kd value of 0.15 uM, blocks the association of G3BP with its binding partners and inhibits condensation of G3BP both in vitro and in live cells.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
G3BP inhibitor b (G3Ib) is a specific, peptide mimetic inhibitor of RNA-binding proteins G3BP1/2 with SPR Kd value of 0.15 uM, blocks the association of G3BP with its binding partners and inhibits condensation of G3BP both in vitro and in live cells.
G3BP inhibitor b (G3Ib) binds the NTF2L domain of G3BP1, disrupts in vitro condensation of RNA, G3BP1, and caprin 1.
G3BP inhibitor b (G3Ib) (50 uM) inhibits stress granule formation in HeLa cells about 82%.
G3BP inhibitor b (G3Ib) (50 uM) reduces eIF3η, PABPC1, and FXR1 puncta, indicating disassembly of stress granules beyond simple extraction of G3BP1, does not influence the rate of translation in cells.
G3BP inhibitor b (G3Ib) prevents the formation of stress granules and dissolves preformed stress granules in human iPSC-derived neurons, dissolves stress granules formed in response to expression of a disease-causing VCP mutant.
| M.Wt | 606.81 | |
| Formula | C35H50N4O5 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Freibaum BD, et al. J Cell Biol. 2024 Mar 4;223(3):e202308083.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
