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Chemical Structure : G6PDi-1
CAS No.: 2457232-14-1
Catalog No.: PC-72918Not For Human Use, Lab Use Only.
G6PDi-1 is a non-steroidal, potent cell active small molecule inhibitor of glucose-6-phosphate dehydrogenase (G6PD) with IC50 of 70 nM (hG6PD).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $228 | In stock | |
| 25 mg | $398 | In stock | |
| 100 mg | $958 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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G6PDi-1 is a non-steroidal, potent cell active small molecule inhibitor of glucose-6-phosphate dehydrogenase (G6PD) with IC50 of 70 nM (hG6PD).
G6PDi-1 binds to G6PD reversibly and non-competitively, binds to G6PD at an allosteric site and inhibits enzyme catalytic activity.
G6PDi-1 dose-dependently decreases 6-PG levels in HepG2 cells with IC50 of 13 uM, decreases 2H transfer from [1-2H]-glucose to NADPH's active hydride in treated HCT116 cells (IC50=31 uM).
G6PDi-1 dose-dependently increases NADP+/NADPH ratio in T cells, suppresses T cell cytokine production while having a minimal effect on initial activation or proliferation, suppresses oxidative burst in bone marrow derived macrophages.
| M.Wt | 284.377 | |
| Formula | C14H12N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-((5-oxo-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-2-yl)amino)thiophene-2-carbonitrile |
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1. Ghergurovich JM, et al. Nat Chem Biol. 2020 Jul;16(7):731-739.
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