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Chemical Structure : GAK inhibitor 12r
Catalog No.: PC-35411Not For Human Use, Lab Use Only.
GAK inhibitor 12r is a higghly potent, selective inhibitor of cyclin G-associated kinase (GAK) with Kd of 89 nM.
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GAK inhibitor 12r is a higghly potent, selective inhibitor of cyclin G-associated kinase (GAK) with Kd of 89 nM; targets only 8 other kinases with greater than 90% inhibition in a diverse panel of 468 kinases; demonstrates broad-spectrum antiviral activity with EC50 of 0.82 uM against DENV-2, also shows activity against dengue virus, including in human primary dendritic cells, and efficacy against the unrelated Ebola and chikungunya viruses.
| M.Wt | 370.471 | |
| Formula | C19H22N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pu SY, et al. J Med Chem. 2018 Jul 16. doi: 10.1021/acs.jmedchem.8b00613.
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