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GAPDS

Chemical Structure : GAPDS

CAS No.: 917773-99-0

GAPDS (GAPDH inhibitor GAPDS)

Catalog No.: PC-62489Not For Human Use, Lab Use Only.

GAPDS is a small molecule that targets the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GAPDS is a small molecule that targets the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH).
GAPDS significantly reduces cellular ATP, shows greater toxicity against cancer cells compared to 6-OHDA, also selectively inhibits cell migration and invasion.
GAPDS reduces GAPDH levels in the cytoplasm, and has potent anticancer activity in vivo.

Physicochemical Properties

M.Wt 573.654
Formula C30H35N7O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2-(2-(2-((4-((3,4-dihydroxyphenethyl)amino)-6-(phenylamino)-1,3,5-triazin-2-yl)amino)ethoxy)ethoxy)ethyl)benzamide

References

1. Jung DW, et al. Chem Biol. 2014 Nov 20;21(11):1533-45.

2. Min J, et al. Nat Chem Biol. 2007 Jan;3(1):55-9.

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